My Tho City is 70km from Vinh Long, 70km from Ho Chi Minh City, 103km from Can Tho City, 179km from Chau Doc, 182km from Rach Gia.

Road: There are bus connections with Vinh Long, Chau Doc, Ca Mau, and other destinations in the Mekong Delta.

Water: A high-speed boat leaves from Ho Chi Minh City daily to My Tho and Can Tho. There is also boat tours around My Tho.