Can Tho is 34km from Vinh Long, 62km from Long Xuyen, 63km from Soc Trang, 104km from My Tho, 116km from Rach Gia, 117km from Chau Doc, 169km from Ho Chi Minh City and 179km from Ca Mau.

Road: Can Tho has National Highway No.1A, 91, 80 linking to An Giang, Kien Giang provinces.

Waterway: Can Tho has Cai Cui international seaport. The city is the centre of waterway network of Mekong Delta. There are daily hydrofoils between Ho Chi Minh City and Can Tho City.

Airline: There is Tra Noc Airport.